European Pain School®

at the University of Siena

European Pain School®

at the University of Siena

EPS 2022 • Pain, Inflammation and the Guts

Siena, Italy • 11-18 June 2022

Pain, Inflammation and the Guts

Siena, Italy • 11-18 June 2022



All times shown in the programme are

Right now, it is HH:mm (dd mmm 'YY) in Siena.


Ln Faculty Lectures (L1-L20)
Sn Scholars’ Oral Presentations (S1-S25)
Wn Interactive Workshops, Seminars and Special Presentations (W1-W8)

  • 11 June
  • 12 June
  • 13 June
  • 14 June
  • 15 June
  • 16 June
  • 17 June
  • 18 June
  • Saturday, 11 June

    11:00-17:00 Arrival of Scholars and Faculty at the Certosa di Pontignano
    Assignment to rooms in the hotel wing of the Certosa. All food during the week will be provided by the restaurant of the Certosa (breakfast, lunch and dinner).
    17:00 Opening Ceremony
    Anna Maria Aloisi, School Director, Siena, Italy
    Molteni, sponsor
    Peter Reeh, Scientific Programme Director, Erlangen, Germany
      L1 Chronic overlapping pain disorders
    Emeran A. Mayer (Los Angeles, CA, USA)
    19:30 Apéritif on the terrace
    20:00 Dinner
    21:30 A guided tour through the Certosa, its Chapel, Cloisters and Garden
    Giancarlo Carli


  • Sunday, 12 June

    9:00-10:00 L2 The Microbiome-Gut-Brain Axis in Pain
    Siobhain O’Mahony (Cork, Ireland)
    10:00-10:15 S1 Neural activity and the immune response in the colon
    Ariel Epouhe (Pittsburgh, PA, USA)
    10:15-10:30 S2 Exploring biopsychosocial mechanisms of abdominal pain in inflammatory bowel disease and irritable bowel syndrome
    Danielle Huisman (London, United Kingdom)
    10:30-11:00 Coffee break
    11:00-11:15 S3 Unravelling the involvement of the descending serotonergic modulation on the DNIC analgesic paradigm in prolonged joint inflammatory pain
    Raquel Pereira-Silva (Oporto, Portugal)
    11:15-11:30 S4 Distinct activity of endocannabinoid-hydrolyzing enzymes MAGL and FAAH in key regions of peripheral and central nervous system implicated in migraine
    Adriana Della Pietra (Kuopio, Finland)
    11:30-12:30 L3 Neuroinflammation and cytokines in spinal hyperexcitability causing joint pain
    Andrea Ebersberger (Jena, Germany)
    13:00-15:00 Lunch break
    15:00-16:00 L4 Pregnancy and beyond: role of the Microbiome-Gut-Brain Axis
    Siobhain O’Mahony (Cork, Ireland)
    16:00-16:15 S5 Investigating the mechanisms underpinning the modulation of visceral sensitivity mediated by faecal microbiota transplantation: focus on the interface between the microbiota and the gut
    Elena Lucarini (Florence, Italy)
    16:15-16:30 S6 Transient receptor potential ankyrin 1 (TRPA1) contributes to mechanical hypersensitivity in a mouse model of endometriosis
    Mustafa Titiz (Florence, Italy)
    16:30-17:00 Coffee break
    17:00-17:15 S7 Investigating central mechanisms of 3% levomenthol treatment on chemotherapy-induced peripheral neuropathy: a phase II placebo-controlled RCT with embedded (f)MRI
    Laura Klinkhamer (Edinburgh, United Kingdom)
    17:15-17:30 S8 Activation of putative nociceptors can modulate the immune profile in the gut
    Kimberly Meerschaert (Boston, MA, USA)
    17:30-18:30 L5 Colonic Pain Models and what they told us
    Peter Reeh (Erlangen, Germany)
    20:00-21:30 Dinner in the small Cloister


  • Monday, 13 June

    9:00-10:00 L6 Visceral pain-associated interoception: influence on emotion, affect and cognition
    Peter Holzer (Graz, Germany)
    10:00-10:15 S9 The role of gut hormone peptide YY in visceral pain
    Aitak Farzi (Graz, Germany)
    10:15-10:30 S10 Influence of kinesiophobia on corticomotor excitability and its relation to top-down pain inhibition
    Arnaud Duport (Sherbrooke, Canada / Calais, France)
    10:30-11:00 Coffee break
    11:00-11:15 S11 Identification of trigeminal sensory neuronal types innervating masseter muscle
    Karen A. Lindquist (San Antonio, TX, USA)
    11:15-11:30 S12 Methylglyoxal-induced effects on axonal properties of human C-fibers
    Miriam M. Düll (Erlangen, Germany)
    11:30-12:30 L7 Plasticity and redundancy in nociceptive mechanisms
    John Wood (London, United Kingdom)
    13:00-15:00 Lunch break
    15:00-16:00 L8 Menstrual pain disorders
    Felice Petraglia (Florence, Italy)
    16:00-16:15 S13 Soy-enriched bread, a pilot study to determine its beneficial effects in menopause
    Ilenia Casini (Siena, Italy)
    16:15-16:30 S14 Exploring the role of childhood trauma on pain modulation for people with endometriosis
    Claire E. Lunde (Oxford, United Kingdom)
    16:30-17:00 Coffee break
    17:00-17:15 S15 Altered anterior insula functional connectivity in adolescent and young women with endometriosis-associated pain: a pilot resting-state fMRI study
    Edina Szabo (Boston, MA, USA)
    17:15-17:30 S16 Altered resting-state functional connectivity between prefrontal and somatosensory cortex after pain response in healthy adults: a pilot functional near-infrared spectroscopy study
    Ziyan Wu (Boston, MA, USA) - Online presentation
    17:30-18:30 L9 Sex differences in chronic visceral pain
    Emeran Mayer (Los Angeles, CA, USA)
    20:00-21:30 Dinner in the small Cloister
    21:30 W1 Debate teams


  • Tuesday, 14 June

    9:00-10:00 L10 Neuroimmune Interactions in Models of Rheumatoid Arthritis
    Marzia Malcangio (London, United Kingdom)
    10:00-10:15 S17 Endoplasmic reticulum stress sensor in chemotherapy-induced peripheral neuropathy (CIPN)
    Miriam M. Fonseca (Winston-Salem, NC, USA)
    10:15-10:30 S18 Immune cells in the dorsal root ganglia could be important contributors to sex differences in pain biology of the rheumatoid arthritis model CAIA
    Zerina Kurtović (Solna, Sweden)
    10:30-11:00 Coffee break
    11:00-11:15 S19 Role of CCL2 in neuropathic pain
    Atlante Mendes (Ribeirão Preto, Brazil)
    11:15-11:30 S20 Contribution of TTX-resistant NaV channels to the generation of membrane potential instabilities in mouse trigeminal neurons
    Enrique Velasco Serna (Leuven, Belgium)
    11:30-12:30 L11 Modulation of sensory transduction by subthreshold membrane potential instabilities
    Karel Talavera (Leuven, Belgium)
    13:00-15:00 Lunch break
    15:00-16:00 W2 Behavioral studies on thermal, mechanical, and spontaneous pain
    Federico Montechiaro & Mauro Uboldi (Ugo Basile Srl, Gemonio, Italy)
    16:00-16:15 S21 Young patients with cerebral palsy exhibit an aberrant somatosensory profile and exaggerated experimentally induced hyperalgesia suggesting a central sensitization subtype of neuropathic pain
    Paul Merz (Mannheim, Germany)
    16:15-16:30 S22 Pain-depressed climbing in male and female mice as a tool for analgesic drug development
    Edna J. Santos (Richmond, VA, USA)
    16:30-17:00 Coffee break
    17:00-17:15 S23 Implications for inflammation and host-microbiome interactions in neurogenic bowel-associated dysfunction and pain after spinal cord injury
    Adam Willits (Kansas City, KS, USA)
    17:15-17:30 S24 Parabrachial modulation of sensory and motivational behaviors in mice
    Yu-Ting Cheng (Boston, MA, USA) - Online presentation
    17:30-18:30 L12 Gut visceral pain: triggers and pathways
    Nathalie Vergnolle (Toulouse, France)
    20:00-21:30 Dinner in the small Cloister
    W3 "Pontignano under the stars"
    Vincenzo Millucci and Alessandro Marchini


  • Wednesday, 15 June

    9:00-10:00 L13 Hormonal modulation of pain
    Anna Maria Aloisi (Siena, Italy)
    10:00-11:00 W4 "Trio"
    Emeran Mayer, Peter Holzer, Nathalie Vergnolle
    11:00-11:30 Coffee break
    11:30-12:30 L14 Control of pain and inflammation: the model of tonic immobility
    Giancarlo Carli (Siena, Italy)
    13:00-15:00 Lunch break
    Afternoon and Evening: excursion to Siena old town


  • Thursday, 16 June

    9:00-10:00 L15 Microbial approaches to treat visceral pain
    Nathalie Vergnolle (Toulouse, France)
    10:00-11:00 L16 Ethics in pain: treatment of babies in pain
    Carlo V. Bellieni (Siena, Italy)
    11:00-11:30 Coffee break
    11:30-11:45 S25 Efficacy of acupuncture and heat-sensitive moxibustion versus electroacupuncture for trigeminal neuralgia
    Katrina R. Hamilton (Baltimore, MD, USA)
    11:45-12:45 L17 QST: from small fiber to central pain processing
    Ofrit Bar-Bachar (Medoc, Ramat Yishai, Israel)
    13:00-15:00 Lunch break
    15:00-16:30 W5 Pain labs
    Ofrit Bar-Bachar (Medoc, Ramat Yishai, Israel) & Peter Reeh (Erlangen, Germany)
    16:30-17:00 Coffee break
      Molteni Symposium
    17:00-18:00 L18 Opioid induced constipation (OIC)
    Flaminia Coluzzi (Rome, Italy)
    18:00-19:00 L19 Cancer Pain and Breakthrough cancer Pain (BTcP)
    Flaminia Coluzzi (Rome, Italy)
    20:00-21:30 Dinner in the small Cloister


  • Friday, 17 June

    9:00-10:00 L20 TRP channels in migraine, neuropathic and cancer pain
    Pierangelo Geppetti (Florence, Italy)
    10:00-10:30 W6 Debate 1
    Irritable bowel syndrome has no organic cause. YES or NO?
    10:30-11:00 Coffee break
    11:00-11:30 W7 Debate 2
    Fecal transplant can change life in health and disease. YES or NO?
    11:30-12:00 W8 Pain Quiz
    12:00-15:00 Lunch break
    15:00-19:00 Rapolano Terme SPA: Antica Querciolaia
    20:00 Dinner at the Certosa


  • Saturday, 18 June